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KMID : 0980220060060020089
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Journal of the Korean Dental Society of Anesthesiology
2006 Volume.6 No. 2 p.89 ~ p.97
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Effect of Submucosal Midazolam on Percutaneous Saturation Percentage of Oxygen (SpO_2), End-tidal Carbon Dioxide (EtCO_2) and Physiologic Response When Combined with Chloral Hydrate, Hydroxyzine and Nitrous Oxide Sedation
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Yoo Ji-Hye
Kim Yoon-Hee
Jung Sang-Hyuk
Baek Kwang-Woo
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Abstract
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Background: The aim of this study was to examine the difference of SpO_2, PR, EtCO_2, RR with submucosal injection of midazolam to oral chloral hydrate and hydroxyzine for pediatric patients
Methods: Thirty two sedation cases were performed in this study. Patients were randomly classified into one group taking oral CH (60 mg/kg). hydroxyzine (1 mg/kg) and submucosal injection of midazolam (0.1 mg/kg) and the other group recieving oral CH (50 mg/kg), hydroxyzine (1 mg/kg) and submucosal injection of midazolam (0.2 mg/kg). For evaluating the depth of sedation. data including saturation percentage of oxygen (SpO_2), pulse rate (PR), end-tidal carbon dioxide (EtCO_2), respiratory rate (RR) and the behavior scale were checked every 2 minutes and were collected for only 40 minutes from the beginning of treatment and were analyzed using Two independent sample T-test.
Results: Analysis showed no significant difference in the mean SpO_2, PR, EtCO_2, RR during sedation between two groups (P > 0.05). The values of SpO_2, PR, EtCO_2 and RR for both groups remained within the normal values.
Conclusions: The results of this present study indicate that combination of oral CH, hydroxyzine, nitrous oxide gas inhalation and submucosal injection of midazolam improved the sedation quality without compromising safety.
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KEYWORD
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Conscious sedation, Submucosal midazolam, Chloral hydrate, Nitrous oxide
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